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MOTS-c (Mitochondrial Open-reading-frame of the Twelve S rRNA type-c) is a 16-amino-acid peptide encoded directly within the mitochondrial genome’s 12S rRNA region — one of only a small number of known mitochondrial-derived peptides (MDPs). Under metabolic stress, MOTS-c has been shown in published research to translocate to the nucleus, where it regulates gene expression tied to stress adaptation.
Research Applications
AMPK activation via the folate/AICAR pathway in skeletal muscle models
Insulin-signaling and glucose-metabolism research in diet-induced metabolic-stress models
Nuclear translocation and antioxidant response element (ARE) gene regulation under metabolic stress
Exercise-adaptation and mitochondrial-nuclear communication research
Specifications
16-amino-acid mitochondrial-derived peptide · Lyophilized powder · 99.26% purity (HPLC-UV/LC-MS, Certificate of Analysis on file, Lot: AX-MS40-081026-001)
